The bomb exploded in Sepoy village in Orakzai district, said senior administration official Zakir Hussain.
"It was remote-controlled bomb planted on the road. The bomb exploded near a pick-up van carrying passengers," Hussain told.
In blast ten people martyred, including two women, an 11-year-old boy and a three-year-old girl, he said, adding that four people were wounded.
Most of the victims were the passengers of the unfortunate van.
Intelligence officials confirmed the blast and the casualties.